UniprotKB/SwissProt ID: P02828 (P02828)
Gene Name:
Hsp83
Organism: Drosophila melanogaster (Fruit fly)
Function: Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction (PubMed:18344983, PubMed:21186352, PubMed:22902557). Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Together with Hop and piwi, mediates canalization, also known as developmental robustness, likely via epigenetic silencing of existing genetic variants and suppression of transposon-induced new genetic variation. Required for piRNA biogenesis by facilitating loading of piRNAs into PIWI proteins (PubMed:21186352, PubMed:22902557)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm
|
|
|
