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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Profilin-1

UniprotKB/SwissProt ID: P02584 (P02584)

Gene Name: PFN1

Organism: Bos taurus (Bovine)

Function: Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR (By similarity)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm, cytoskeleton

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR048278 PFN
IPR005455 PFN_euk
IPR036140 PFN_sf
IPR005454 Profilin1/2/3_vertebrate
IPR027310 Profilin_CS

The S-nitrosylation sites of P02584

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 128 GVHGGMINKK C YEMASHLRRS