UniprotKB/SwissProt ID: P01210 (P01210)
Gene Name:
PENK
Organism: Homo sapiens (Human)
Function: Neuropeptide that competes with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress Neuropeptide that competes with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress Met-enkephalin-Arg-Phe neuropeptide acts as a strong ligand of Mu-type opioid receptor OPRM1. Met-enkephalin-Arg-Phe-binding to OPRM1 in the nucleus accumbens of the brain increases activation of OPRM1, leading to long-term synaptic depression of glutamate release Increases glutamate release in the striatum and decreases GABA concentration in the striatum Increases glutamate release in the striatum
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasmic vesicle, secretory vesicle, chromaffin granule lumen. Secreted
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