Protein Name:
Low-density lipoprotein receptor
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UniprotKB/SwissProt ID: P01130 (P01130)
Gene Name:
LDLR
Organism: Homo sapiens (Human)
Function: Binds low density lipoprotein /LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Forms a ternary complex with PGRMC1 and TMEM97 receptors which increases LDLR-mediated LDL internalization (PubMed:30443021) (Microbial infection) Acts as a receptor for hepatitis C virus in hepatocytes, but not through a direct interaction with viral proteins (Microbial infection) Acts as a receptor for Vesicular stomatitis virus (Microbial infection) In case of HIV-1 infection, may function as a receptor for extracellular Tat in neurons, mediating its internalization in uninfected cells (Microbial infection) Acts as a receptor for Crimean-Congo hemorrhagic fever virus (CCHFV) (Microbial infection) Acts as a receptor for many Alphavirus, including Getah virus (GETV), Ross river virus (RRV) and Semliki Forest virus
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Membrane, clathrin-coated pit. Golgi apparatus. Early endosome. Late endosome. Lysosome
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P01130
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
452 |
YWSDLSQRMI C STQLDRAHGV |
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| 2 |
839 |
QKTTEDEVHI C HNQDGYSYPS |
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