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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: GTPase HRas

UniprotKB/SwissProt ID: P01112 (P01112)

Gene Name: HRAS

Organism: Homo sapiens (Human)

Function: Involved in the activation of Ras protein signal transduction (PubMed:22821884). Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (PubMed:12740440, PubMed:14500341, PubMed:9020151)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cell membrane. Golgi apparatus. Golgi apparatus membrane. Nucleus. Cytoplasm. Cytoplasm, perinuclear region

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd
IPR001806 Small_GTPase
IPR020849 Small_GTPase_Ras-type

The S-nitrosylation sites of P01112

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 118 DVPMVLVGNK C DLAARTVESR  CCCEEEEEEC C CCCCHHHHHH  6.34% 9020151
2 181 LNPPDESGPG C MSCKCVLS--  CCCEEEEEEC C CCCCHHHHHH  1.72% 24105792
3 184 PDESGPGCMS C KCVLS-----  CCCEEEEEEC C CCCCHHHHHH  1.25%
4 186 ESGPGCMSCK C VLS-------  CCCEEEEEEC C CCCCHHHHHH  4.34%
5 80 QYMRTGEGFL C VFAINNTKSF  CCCEEEEEEC C CCCCHHHHHH  1.9% 24105792