Protein Name:
Alpha-1-antitrypsin
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UniprotKB/SwissProt ID: P01009 (P01009)
Gene Name:
SERPINA1
Organism: Homo sapiens (Human)
Function: Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin Reversible chymotrypsin inhibitor. It also inhibits elastase, but not trypsin. Its major physiological function is the protection of the lower respiratory tract against proteolytic destruction by human leukocyte elastase (HLE)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Secreted. Endoplasmic reticulum. Secreted, extracellular space, extracellular matrix
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P01009
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
256 |
KRLGMFNIQH C KKLSSWVLLM |
CCCHHHHHHH H HHHHHHHEEH |
2.08% |
22178444
25040305
10673391
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