Protein Name:
Tissue-type plasminogen activator
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UniprotKB/SwissProt ID: P00750 (P00750)
Gene Name:
PLAT
Organism: Homo sapiens (Human)
Function: Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. During oocyte activation, plays a role in cortical granule reaction in the zona reaction, which contributes to the block to polyspermy (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Secreted, extracellular space
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P00750
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
118 |
CQCPEGFAGK C CEIDTRATCY |
CHHHHHHHHH H HHHHCCEEEC |
2.17% |
22178444
1325644
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