Protein Name:
Phosphoglycerate kinase 1
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UniprotKB/SwissProt ID: P00558 (P00558)
Gene Name:
PGK1
Organism: Homo sapiens (Human)
Function: Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate (PubMed:30323285, PubMed:7391028). Both L- and D- forms of purine and pyrimidine nucleotides can be used as substrates, but the activity is much lower on pyrimidines (PubMed:18463139). In addition to its role as a glycolytic enzyme, it seems that PGK1 acts as a polymerase alpha cofactor protein (primer recognition protein) (PubMed:2324090). Acts as a protein kinase when localized to the mitochondrion where it phosphorylates pyruvate dehydrogenase kinase PDK1 to inhibit pyruvate dehydrogenase complex activity and suppress the formation of acetyl-coenzyme A from pyruvate, and consequently inhibit oxidative phosphorylation and promote glycolysis (PubMed:26942675, PubMed:36849569). May play a role in sperm motility (PubMed:26677959)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm, cytosol. Mitochondrion matrix
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P00558
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
108 |
DCVGPEVEKA C ANPAAGSVIL |
CCCCCCCCCC C CCCCCCEEEE |
5.79% |
18335467
19483679
20140087
22178444
37478858
|
| 2 |
316 |
GIPAGWMGLD C GPESSKKYAE |
CCCCCCCCCC C CCCCCCEEEE |
13.57% |
|
| 3 |
367 |
DEVVKATSRG C ITIIGGGDTA |
CCCCCCCCCC C CCCCCCEEEE |
2.11% |
22178444
|
| 4 |
379 |
TIIGGGDTAT C CAKWNTEDKV |
CCCCCCCCCC C CCCCCCEEEE |
1.65% |
22178444
|
| 5 |
380 |
IIGGGDTATC C AKWNTEDKVS |
CCCCCCCCCC C CCCCCCEEEE |
3.66% |
22178444
|
| 6 |
50 |
IKAAVPSIKF C LDNGAKSVVL |
CCCCCCCCCC C CCCCCCEEEE |
3.86% |
22178444
18335467
17629318
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| 7 |
99 |
LGKDVLFLKD C VGPEVEKACA |
CCCCCCCCCC C CCCCCCEEEE |
3.49% |
22178444
20140087
37478858
|
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