Protein Name:
Glutamate dehydrogenase 1, mitochondrial
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UniprotKB/SwissProt ID: P00367 (P00367)
Gene Name:
GLUD1
Organism: Homo sapiens (Human)
Function: Mitochondrial glutamate dehydrogenase that catalyzes the conversion of L-glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle (PubMed:11032875, PubMed:11254391, PubMed:16023112, PubMed:16959573). Plays a role in insulin homeostasis (PubMed:11297618, PubMed:9571255). May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Mitochondrion. Endoplasmic reticulum
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P00367
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
112 |
VRGILRIIKP C NHVLSLSFPI |
CCCCHHHHHH H HCCCCCHHCC |
4.7% |
24105792
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| 2 |
146 |
RAQHSQHRTP C KGGIRYSTDV |
CCCCHHHHHH H HCCCCCHHCC |
6.73% |
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| 3 |
172 |
KALASLMTYK C AVVDVPFGGA |
CCCCHHHHHH H HCCCCCHHCC |
2.15% |
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| 4 |
327 |
MRYLHRFGAK C IAVGESDGSI |
CCCCHHHHHH H HCCCCCHHCC |
2.09% |
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| 5 |
376 |
PYEGSILEAD C DILIPAASEK |
CCCCHHHHHH H HCCCCCHHCC |
4.52% |
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