Protein Name:
3'(2'),5'-bisphosphate nucleotidase 1
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UniprotKB/SwissProt ID: O95861 (O95861)
Gene Name:
BPNT1
Organism: Homo sapiens (Human)
Function: Phosphatase that converts 3'(2')-phosphoadenosine 5'-phosphate (PAP) to AMP and inositol 1,4-bisphosphate (Ins(1,4)P2) to inositol 4-phosphate (PubMed:10675562). Is also able to hydrolyze adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) (By similarity). Probably prevents the toxic accumulation of PAP, a compound which inhibits a variety of proteins, including PAPS-utilizing enzymes such as sulfotransferases, and RNA processing enzymes. Could also play a role in inositol recycling and phosphoinositide metabolism. Is not active on 3'-AMP, inositol-1-phosphate and inositol-1,4,5-triphosphate (PubMed:10675562)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization:
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of O95861
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
100 |
SQWEEILKQP C PSQYSAIKEE |
CCCCHHHHHH H HHHHHHHHHH |
4.73% |
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| 2 |
206 |
RSHSNKLVTD C VAAMNPDAVL |
CCCCHHHHHH H HHHHHHHHHH |
1.31% |
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| 3 |
243 |
ASAYVFASPG C KKWDTCAPEV |
CCCCHHHHHH H HHHHHHHHHH |
4.68% |
19483679
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| 4 |
249 |
ASPGCKKWDT C APEVILHAVG |
CCCCHHHHHH H HHHHHHHHHH |
5.72% |
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| 5 |
42 |
EGDLGIVEKT C ATDLQTKADR |
CCCCHHHHHH H HHHHHHHHHH |
5.94% |
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| 6 |
59 |
KADRLAQMSI C SSLARKFPKL |
CCCCHHHHHH H HHHHHHHHHH |
1.45% |
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