Protein Name:
Chloride intracellular channel protein 3
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UniprotKB/SwissProt ID: O95833 (O95833)
Gene Name:
CLIC3
Organism: Homo sapiens (Human)
Function: In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor (PubMed:28198360, PubMed:37759794). Reduced in a glutathione-dependent way and secreted into the extracellular matrix where it activates TGM2 and promotes blood vessel growth during tissue remodeling as occurs in tumorigenesis. Can reduce specific cysteines in TGM2 and regulate cofactor binding (PubMed:28198360). Can insert into membranes and form outwardly rectifying chloride ion channels. May participate in cellular growth control
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Membrane. Cell membrane. Cytoplasm. Secreted, extracellular space, extracellular matrix
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of O95833
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
174 |
LDGDRLTLAD C SLLPKLHIVD |
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