Protein Name:
E3 ubiquitin-protein ligase HERC2
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UniprotKB/SwissProt ID: O95714 (O95714)
Gene Name:
HERC2
Organism: Homo sapiens (Human)
Function: E3 ubiquitin-protein ligase that regulates ubiquitin-dependent retention of repair proteins on damaged chromosomes. Recruited to sites of DNA damage in response to ionizing radiation (IR) and facilitates the assembly of UBE2N and RNF8 promoting DNA damage-induced formation of 'Lys-63'-linked ubiquitin chains. Acts as a mediator of binding specificity between UBE2N and RNF8. Involved in the maintenance of RNF168 levels. E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of XPA which influences the circadian oscillation of DNA excision repair activity. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). Also modulates iron metabolism by regulating the basal turnover of FBXL5 (PubMed:24778179)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Nucleus
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of O95714
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
1825 |
QTALRLIGPS C DNVEEDMNAS |
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| 2 |
2760 |
INEPGQSAVF C GRSGKQLKRC |
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| 3 |
349 |
PLLQRFQSII C RKDAPHSEGD |
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| 4 |
914 |
RARALSALLP C AVSGNEVNIS |
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