Protein Name:
Probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein
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UniprotKB/SwissProt ID: O95671 (O95671)
Gene Name:
ASMTL
Organism: Homo sapiens (Human)
Function: Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. Can also hydrolyze CTP and the modified nucleotides pseudo-UTP, 5-methyl-UTP (m(5)UTP) and 5-methyl-CTP (m(5)CTP). Has weak activity with dCTP, 8-oxo-GTP and N(4)-methyl-dCTP (PubMed:24210219). May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids (PubMed:24210219). In addition, the presence of the putative catalytic domain of S-adenosyl-L-methionine binding in the C-terminal region argues for a methyltransferase activity (Probable)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization:
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of O95671
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
274 |
EAGQATAEAE C HRTRETLPPF |
CCCCHHHHHH H HHHHHEECCC |
3.2% |
22178444
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| 2 |
333 |
DIASKVDASA C GMERLLDICA |
CCCCHHHHHH H HHHHHEECCC |
5.03% |
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| 3 |
441 |
AMHGMTKLTA C QVATAFNLSR |
CCCCHHHHHH H HHHHHEECCC |
2.55% |
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