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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Cleavage and polyadenylation specificity factor subunit 4

UniprotKB/SwissProt ID: O95639 (O95639)

Gene Name: CPSF4

Organism: Homo sapiens (Human)

Function: Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR045348 CPSF4/Yth1
IPR041686 Znf-CCCH_3
IPR000571 Znf_CCCH
IPR036855 Znf_CCCH_sf
IPR001878 Znf_CCHC
IPR036875 Znf_CCHC_sf

The S-nitrosylation sites of O95639

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 110 SKFGECSNKE C PFLHIDPESK   
2 124 HIDPESKIKD C PWYDRGFCKH   
3 55 LKAACGKGGM C PFRHISGEKT