Protein Name:
Fatty acid CoA ligase Acsl3
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UniprotKB/SwissProt ID: O95573 (O95573)
Gene Name:
ACSL3
Organism: Homo sapiens (Human)
Function: Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:22633490). Required for the incorporation of fatty acids into phosphatidylcholine, the major phospholipid located on the surface of VLDL (very low density lipoproteins) (PubMed:18003621). Has mainly an anabolic role in energy metabolism. Mediates hepatic lipogenesis. Preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates. Both isoforms exhibit the same level of activity (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Mitochondrion outer membrane. Peroxisome membrane. Microsome membrane. Endoplasmic reticulum membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of O95573
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
166 |
QKPKTNIAIF C ETRAEWMIAA |
CCCCCCCCCC H HHHHHHHHHH |
4.22% |
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| 2 |
429 |
QISKGRNTPL C DSFVFRKVRS |
CCCCCCCCCC H HHHHHHHHHH |
4.3% |
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| 3 |
450 |
LLGGNIRLLL C GGAPLSATTQ |
CCCCCCCCCC H HHHHHHHHHH |
4.82% |
22178444
18335467
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| 4 |
561 |
FEDENGQRWL C TGDIGEFEPD |
CCCCCCCCCC H HHHHHHHHHH |
2.95% |
19483679
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| 5 |
573 |
GDIGEFEPDG C LKIIDRKKDL |
CCCCCCCCCC H HHHHHHHHHH |
4.57% |
19483679
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| 6 |
85 |
DGLASVLYPG C DTLDKVFTYA |
CCCCCCCCCC H HHHHHHHHHH |
2.89% |
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