Protein Name:
Activator of 90 kDa heat shock protein ATPase homolog 1
|
UniprotKB/SwissProt ID: O95433 (O95433)
Gene Name:
AHSA1
Organism: Homo sapiens (Human)
Function: Acts as a co-chaperone of HSP90AA1 (PubMed:29127155). Activates the ATPase activity of HSP90AA1 leading to increase in its chaperone activity (PubMed:29127155). Competes with the inhibitory co-chaperone FNIP1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:27353360). Competes with the inhibitory co-chaperone TSC1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:29127155)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm, cytosol. Endoplasmic reticulum
|
|
|
Graphical Visualization of S-nitrosylation Sites:
|
|
The S-nitrosylation sites of O95433
|
| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
207 |
ARPVGVKIPT C KITLKETFLT |
CCCCCCCCCC E EEEECCCCCC |
2.23% |
19483679
|
| 2 |
301 |
FIDKNGETEL C MEGRGIPAPE |
CCCCCCCCCC E EEEECCCCCC |
1.58% |
|
| 3 |
56 |
AVQVQNEEGK C EVTEVSKLDG |
CCCCCCCCCC E EEEECCCCCC |
8.16% |
|
|
