UniprotKB/SwissProt ID: O95390 (O95390)
Gene Name:
GDF11
Organism: Homo sapiens (Human)
Function: Secreted signal that acts globally to regulate anterior/posterior axial patterning during development. May play critical roles in patterning both mesodermal and neural tissues (By similarity). It is required for proper vertebral patterning and orofacial development (PubMed:31215115). Signals through activin receptors type-2, ACVR2A and ACVR2B, and activin receptors type-1, ACVR1B, ACVR1C and TGFBR1 leading to the phosphorylation of SMAD2 and SMAD3 (PubMed:28257634)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Secreted
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