Protein Name:
Acyl-protein thioesterase 2
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UniprotKB/SwissProt ID: O95372 (O95372)
Gene Name:
LYPLA2
Organism: Homo sapiens (Human)
Function: Acts as an acyl-protein thioesterase hydrolyzing fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins, GSDMD, GAP43, ZDHHC6 or HRAS (PubMed:21152083, PubMed:28826475). Deacylates GAP43 (PubMed:21152083). Mediates depalmitoylation of ZDHHC6 (PubMed:28826475). Has lysophospholipase activity (PubMed:25301951). Hydrolyzes prostaglandin glycerol esters (PG-Gs) in the following order prostaglandin D2-glycerol ester (PGD2-G) > prostaglandin E2 glycerol ester (PGE2-G) > prostaglandin F2-alpha-glycerol ester (PGF2-alpha-G) (PubMed:25301951). Hydrolyzes 1-arachidonoylglycerol but not 2-arachidonoylglycerol or arachidonoylethanolamide (PubMed:25301951)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of O95372
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
171 |
GSAKDLAILQ C HGELDPMVPV |
CCCCCCCCEE E CCCCCCCCCH |
3.9% |
37478858
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| 2 |
213 |
KTYPGVMHSS C PQEMAAVKEF |
CCCCCCCCEE E CCCCCCCCCH |
4.52% |
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| 3 |
56 |
TIRLPHVKYI C PHAPRIPVTL |
CCCCCCCCEE E CCCCCCCCCH |
1.51% |
19483679
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