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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Phenylalanine--tRNA ligase, mitochondrial

UniprotKB/SwissProt ID: O95363 (O95363)

Gene Name: FARS2

Organism: Homo sapiens (Human)

Function: Is responsible for the charging of tRNA(Phe) with phenylalanine in mitochondrial translation. To a lesser extent, also catalyzes direct attachment of m-Tyr (an oxidized version of Phe) to tRNA(Phe), thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of ROS-damaged amino acid into proteins

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Mitochondrion matrix. Mitochondrion

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR006195 aa-tRNA-synth_II
IPR045864 aa-tRNA-synth_II/BPL/LPL
IPR005121 Fdx_antiC-bd
IPR036690 Fdx_antiC-bd_sf
IPR004530 Phe-tRNA-synth_IIc_mito
IPR002319 Phenylalanyl-tRNA_Synthase

The S-nitrosylation sites of O95363

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 344 CEDERFLKQF C VSNINQKVKF