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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Methyl-CpG-binding domain protein 4

UniprotKB/SwissProt ID: O95243 (O95243)

Gene Name: MBD4

Organism: Homo sapiens (Human)

Function: Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR016177 DNA-bd_dom_sf
IPR011257 DNA_glycosylase
IPR017352 MBD4
IPR045138 MeCP2/MBD4
IPR001739 Methyl_CpG_DNA-bd

The S-nitrosylation sites of O95243

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 82 AQFGATAGTE C RKSVPCGWER