Protein Name:
Reticulon-3
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UniprotKB/SwissProt ID: O95197 (O95197)
Gene Name:
RTN3
Organism: Homo sapiens (Human)
Function: May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. Induces the formation of endoplasmic reticulum tubules (PubMed:25612671). Also acts as an inflammation-resolving regulator by interacting with both TRIM25 and RIGI, subsequently impairing RIGI 'Lys-63'-linked polyubiquitination leading to IRF3 and NF-kappa-B inhibition (Microbial infection) Plays a positive role in viral replication and pathogenesis of enteroviruses
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Endoplasmic reticulum membrane. Golgi apparatus membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of O95197
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
582 |
LGRSPASEAA C SKVPDTNVSL |
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