Protein Name:
Elongator complex protein 1
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UniprotKB/SwissProt ID: O95163 (O95163)
Gene Name:
ELP1
Organism: Homo sapiens (Human)
Function: Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (PubMed:29332244). The elongator complex catalyzes the formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (PubMed:29332244). Regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation (By similarity). ELP1 binds to tRNA, mediating interaction of the elongator complex with tRNA (By similarity). May act as a scaffold protein that assembles active IKK-MAP3K14 complexes (IKKA, IKKB and MAP3K14/NIK) (PubMed:9751059)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Nucleus
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of O95163
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
1025 |
HEKALSAFLT C GNWKQALCVA |
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| 2 |
213 |
DGQFFAVSVV C PETGARKVRV |
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| 3 |
23 |
RDIQGPGNPQ C FSLRTEQGTV |
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| 4 |
341 |
YLKQSLSFST C GKSKIVSLMW |
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| 5 |
456 |
NQISVYKCGD C PSADPTVKLG |
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