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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Glutaminase kidney isoform, mitochondrial

UniprotKB/SwissProt ID: O94925 (O94925)

Gene Name: GLS

Organism: Homo sapiens (Human)

Function: Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate, the main excitatory neurotransmitter in the brain (PubMed:30239721, PubMed:30575854, PubMed:30970188) Lacks catalytic activity

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Mitochondrion. Cytoplasm, cytosol. Mitochondrion. Mitochondrion matrix. Mitochondrion matrix

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR002110 Ankyrin_rpt
IPR036770 Ankyrin_rpt-contain_sf
IPR012338 Beta-lactam/transpept-like
IPR015868 Glutaminase
IPR041541 Glutaminase_EF-hand

The S-nitrosylation sites of O94925

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 266 FSPDLWGVSV C TVDGQRHSTG