Protein Name:
Mitochondrial import receptor subunit TOM70
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UniprotKB/SwissProt ID: O94826 (O94826)
Gene Name:
TOMM70
Organism: Homo sapiens (Human)
Function: Acts as a receptor of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) (PubMed:12526792). Recognizes and mediates the translocation of mitochondrial preproteins from the cytosol into the mitochondria in a chaperone dependent manner (PubMed:12526792, PubMed:35025629). Mediates TBK1 and IRF3 activation induced by MAVS in response to Sendai virus infection and promotes host antiviral responses during virus infection (PubMed:20628368, PubMed:25609812, PubMed:32728199). Upon Sendai virus infection, recruits HSP90AA1:IRF3:BAX in mitochondrion and the complex induces apoptosis (PubMed:25609812)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Mitochondrion outer membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of O94826
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
144 |
IQCYTEAISL C PTEKNVDLST |
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| 2 |
176 |
LQKWKEVAQD C TKAVELNPKY |
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| 3 |
214 |
KECLEDVTAV C ILEGFQNQQS |
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| 4 |
317 |
EENYDKIISE C SKEIDAEGKY |
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| 5 |
427 |
VEEAVADFDE C IRLRPESALA |
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| 6 |
442 |
PESALAQAQK C FALYRQAYTG |
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| 7 |
475 |
FEEVIKKFPR C AEGYALYAQA |
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| 8 |
502 |
FGKADEMYDK C IDLEPDNATT |
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| 9 |
544 |
ISKAIEIDNK C DFAYETMGTI |
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