Protein Name:
E3 ubiquitin-protein ligase listerin
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UniprotKB/SwissProt ID: O94822 (O94822)
Gene Name:
LTN1
Organism: Homo sapiens (Human)
Function: E3 ubiquitin-protein ligase component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation (PubMed:23685075, PubMed:25132172, PubMed:25578875, PubMed:28757607). Within the RQC complex, LTN1 is recruited to stalled 60S ribosomal subunits by NEMF and mediates ubiquitination of stalled nascent chains (PubMed:25578875). Ubiquitination leads to VCP/p97 recruitment for extraction and degradation of the incomplete translation product (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm, cytosol
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of O94822
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
555 |
ILESNKENEK C VSSEGEKIEG |
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| 2 |
869 |
EKTHLPDFLI C KLKNTWLSGV |
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| 3 |
981 |
LEGRLSLNYE C FKTDFKEQDI |
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