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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Serine/threonine-protein kinase 10

UniprotKB/SwissProt ID: O94804 (O94804)

Gene Name: STK10

Organism: Homo sapiens (Human)

Function: Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cell membrane

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR011009 Kinase-like_dom_sf
IPR022165 PKK
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
IPR051585 STE20_Ser/Thr_Kinases
IPR042743 STK10_STKc

The S-nitrosylation sites of O94804

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 888 SELQQLQNEK C HLLVEHETQK