Protein Name:
Ubiquitin carboxyl-terminal hydrolase 1
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UniprotKB/SwissProt ID: O94782 (O94782)
Gene Name:
USP1
Organism: Homo sapiens (Human)
Function: Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2 (PubMed:15694335). Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA (PubMed:16531995, PubMed:20147293). Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity (PubMed:18082604, PubMed:26388029)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of O94782
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
376 |
GVKGQSKENE C DPEEDLGKCE |
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| 2 |
619 |
DKGNFVVDQM C EIGKPEPLNE |
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