Protein Name:
Thioredoxin reductase 1, cytoplasmic
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UniprotKB/SwissProt ID: O89049 (O89049)
Gene Name:
Txnrd1
Organism: Rattus norvegicus (Rat)
Function: Reduces disulfideprotein thioredoxin (Trx) to its dithiol-containing form. Homodimeric flavoprotein involved in the regulation of cellular redox reactions, growth and differentiation. Contains a selenocysteine residue at the C-terminal active site that is essential for catalysis (PubMed:10849437). Also has reductase activity on hydrogen peroxide (H2O2) (PubMed:10849437)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm
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Graphical Visualization of S-nitrosylation Sites:
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