UniprotKB/SwissProt ID: O89017 (O89017)
Gene Name:
Lgmn
Organism: Mus musculus (Mouse)
Function: Has a strict specificity for hydrolysis of asparaginyl bonds (PubMed:24407422, PubMed:9742219, PubMed:9891971). Can also cleave aspartyl bonds slowly, especially under acidic conditions (PubMed:24407422, PubMed:9742219, PubMed:9891971). Involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system (By similarity). Also involved in MHC class I antigen presentation in cross-presenting dendritic cells by mediating cleavage and maturation of Perforin-2 (MPEG1), thereby promoting antigen translocation in the cytosol (PubMed:37347855). Required for normal lysosomal protein degradation in renal proximal tubules (PubMed:17350006, PubMed:21292981). Required for normal degradation of internalized EGFR (PubMed:21292981). Plays a role in the regulation of cell proliferation via its role in EGFR degradation (PubMed:21292981)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Lysosome
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