Protein Name:
Adhesion G protein-coupled receptor L2
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UniprotKB/SwissProt ID: O88923 (O88923)
Gene Name:
Adgrl2
Organism: Rattus norvegicus (Rat)
Function: Orphan adhesion G-protein coupled receptor (aGPCR), which mediates synapse specificity (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (By similarity). Following G-protein coupled receptor activation, associates with cell adhesion molecules that are expressed at the surface of adjacent cells to direct synapse specificity. Specifically mediates the establishment of perforant-path synapses on CA1-region pyramidal neurons in the hippocampus. Localizes to postsynaptic spines in excitatory synapses in the S.lacunosum-moleculare and interacts with presynaptic cell adhesion molecules, such as teneurins, promoting synapse formation (By similarity) Calcium-independent receptor of low affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Postsynaptic cell membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of O88923
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
811 |
TMMGYWSTQG C KLVDTNKTRT |
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