Protein Name:
Growth factor receptor-bound protein 14
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UniprotKB/SwissProt ID: O88900 (O88900)
Gene Name:
Grb14
Organism: Rattus norvegicus (Rat)
Function: Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Endosome membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of O88900
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
27 |
AQDSPLAVQV C RVAQGKGDAQ |
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