UniprotKB/SwissProt ID: O88845 (O88845)
Gene Name:
Akap10
Organism: Mus musculus (Mouse)
Function: Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A and anchors them to the mitochondria or the plasma membrane. Although the physiological relevance between PKA and AKAPS with mitochondria is not fully understood, one idea is that BAD, a proapoptotic member, is phosphorylated and inactivated by mitochondria-anchored PKA. It cannot be excluded too that it may facilitate PKA as well as G protein signal transduction, by acting as an adapter for assembling multiprotein complexes. With its RGS domain, it could lead to the interaction to G-alpha proteins, providing a link between the signaling machinery and the downstream kinase
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Mitochondrion. Membrane. Cytoplasm
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