Protein Name:
Junctional adhesion molecule A
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UniprotKB/SwissProt ID: O88792 (O88792)
Gene Name:
F11r
Organism: Mus musculus (Mouse)
Function: Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3 (PubMed:11447115). The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly (PubMed:11447115). Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier (PubMed:9660867). Ligand for integrin alpha-L/beta-2 involved in memory T-cell and neutrophil transmigration (By similarity). Involved in platelet activation (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell junction, tight junction. Cell membrane
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Graphical Visualization of S-nitrosylation Sites:
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