Protein Name:
Protein bassoon
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UniprotKB/SwissProt ID: O88778 (O88778)
Gene Name:
Bsn
Organism: Rattus norvegicus (Rat)
Function: Scaffold protein of the presynaptic cytomatrix at the active zone (CAZ) which is the place in the synapse where neurotransmitter is released (PubMed:22875941). After synthesis, participates in the formation of Golgi-derived membranous organelles termed Piccolo-Bassoon transport vesicles (PTVs) that are transported along axons to sites of nascent synaptic contacts (PubMed:22875941). At the presynaptic active zone, regulates the spatial organization of synaptic vesicle cluster, the protein complexes that execute membrane fusion and compensatory endocytosis (PubMed:27907191). Also functions in processes other than assembly such as the regulation of specific presynaptic protein ubiquitination by interacting with SIAH1 or the regulation of presynaptic autophagy by associating with ATG5 (PubMed:23403927, PubMed:27907191). Also mediates synapse to nucleus communication leading to reconfiguration of gene expression by associating with the transcriptional corepressor CTBP1 and by subsequently reducing the size of its pool available for nuclear import (PubMed:25652077). Inhibits the activity of the proportion of DAO enzyme that localizes to the presynaptic active zone, which may modulate synaptic transmission (PubMed:21700703)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Presynaptic active zone. Cytoplasm, cytoskeleton. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of O88778
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
2560 |
RHSMPRLRDA C EPESGPDPST |
CCCCCCCCCC C CCCCCCCCCC |
11.97% |
16418269
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