UniprotKB/SwissProt ID: O88736 (O88736)
Gene Name:
Hsd17b7
Organism: Mus musculus (Mouse)
Function: Bifunctional enzyme involved in steroid-hormone metabolism and cholesterol biosynthesis (PubMed:12732193, PubMed:12829805, PubMed:20659585, PubMed:9658408). Catalyzes the NADP(H)-dependent reduction of estrogens and androgens and regulates the biological potency of these steroids. Converts estrone (E1)to a more potent estrogen, 17beta-estradiol (E2) (PubMed:12732193, PubMed:9658408). Converts moderately dihydrotestosterone (DHT) to their inactive forms 5a-androstane-3beta,17b-diol and 5alpha-androstane-3alpha,17beta-diol (PubMed:12732193). Does not metabolize progesterone (PubMed:12732193). Additionally, participates in the post-squalene cholesterol biosynthesis, as a 3-ketosteroid reductase (PubMed:12829805, PubMed:20659585)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Endoplasmic reticulum membrane
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