Protein Name:
Low-density lipoprotein receptor-related protein 6
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UniprotKB/SwissProt ID: O88572 (O88572)
Gene Name:
Lrp6
Organism: Mus musculus (Mouse)
Function: Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalosomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin (By similarity). Required for posterior patterning of the epiblast during gastrulation (PubMed:15142971)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Endoplasmic reticulum. Membrane raft
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Graphical Visualization of S-nitrosylation Sites:
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