UniprotKB/SwissProt ID: O76742 (O76742)
Gene Name:
Rab7
Organism: Drosophila melanogaster (Fruit fly)
Function: Small GTPase which cycles between active GTP-bound and inactive GDP-bound states (Probable). In its active state, binds to a variety of effector proteins playing a key role in the regulation of endo-lysosomal trafficking (Probable). Involved in microtubule minus and plus end-directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades (Probable). Governs early-to-late endosomal to lysosomal maturation (PubMed:23418349, PubMed:24327558). Controls endocytic cargo sorting towards the late endosome facilitating its eventual endolysosomal-mediated degradation (PubMed:11136982). Together with Rab2 involved in promoting fusion of autophagosomes and endosomes with lysosomes probably through recruitment of the HOPS tethering complex (PubMed:28063257, PubMed:28483915, PubMed:31194677). Involved in biosynthetic transport to lysosomes (Probable). Involved in establishing morphogen concentration gradients, for example of the TGF-beta homolog dpp/decapentaplegic, during pattern formation and organogenesis (PubMed:11136982). Together with the Mon1-Ccz1 complex, required for autolysosome formation in fat cells and autophagic degradation during starvation-induced basal and developmental autophagy (PubMed:27559127). Together with Mon1, regulates levels of postsynaptic glutamate receptor GluRIIA in the neuromuscular junction (NMJ) presynapse (PubMed:32658990). Required for autophagocytosis-dependent remodeling of myofibrils and transverse-tubules (T-tubules) during metamorphosis (PubMed:28063257). Involved in intracellular trafficking of the carbohydrate transporter Tret1 in glial cells of the blood brain barrier, influencing its subcellular localization and protein levels (PubMed:34032568)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Early endosome membrane. Late endosome membrane. Lysosome membrane. Cytoplasmic vesicle, autophagosome membrane. Autolysosome membrane. Presynapse. Perikaryon
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