Protein Name:
AN1-type zinc finger protein 5
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UniprotKB/SwissProt ID: O76080 (O76080)
Gene Name:
ZFAND5
Organism: Homo sapiens (Human)
Function: Involved in protein degradation via the ubiquitin-proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Also inhibits tumor necrosis factor (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of O76080
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
168 |
RKKVGLTGFD C RCGNLFCGLH |
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| 2 |
186 |
GLHRYSDKHN C PYDYKAEAAA |
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| 3 |
76 |
VQRADTSLNN C EGAAGSTSEK |
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