Protein Name:
Probable cytosolic iron-sulfur protein assembly protein CIAO1
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UniprotKB/SwissProt ID: O76071 (O76071)
Gene Name:
CIAO1
Organism: Homo sapiens (Human)
Function: Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins (PubMed:17937914, PubMed:23891004, PubMed:38950322). As a CIA complex component, interacts specifically with CIAO2A or CIAO2B and MMS19 to assist different branches of iron-sulfur protein assembly, depending of its interactors. The complex CIAO1:CIAO2B:MMS19 binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins. CIAO1:CIAO2A specifically matures ACO1 and stabilizes IREB2 (PubMed:23891004). Seems to specifically modulate the transactivation activity of WT1 (PubMed:9556563). As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation (PubMed:20797633)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of O76071
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
123 |
WAPSGNLLAT C SRDKSVWVWE |
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| 2 |
142 |
WEVDEEDEYE C VSVLNSHTQD |
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| 3 |
187 |
YREEEDDWVC C ATLEGHESTV |
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| 4 |
212 |
FDPSGQRLAS C SDDRTVRIWR |
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| 5 |
234 |
YLPGNEQGVA C SGSDPSWKCI |
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| 6 |
245 |
SGSDPSWKCI C TLSGFHSRTI |
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| 7 |
271 |
CQLTGALATA C GDDAIRVFQE |
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| 8 |
322 |
NPKEPGLLAS C SDDGEVAFWK |
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| 9 |
52 |
IWGTEGDSWI C KSVLSEGHQR |
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| 10 |
97 |
IWKKNQDDFE C VTTLEGHENE |
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