Protein Name:
ATP-dependent clpX-like chaperone, mitochondrial
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UniprotKB/SwissProt ID: O76031 (O76031)
Gene Name:
CLPX
Organism: Homo sapiens (Human)
Function: ATP-dependent chaperone that functions as an unfoldase. As part of the ClpXP protease complex, it recognizes specific protein substrates, unfolds them using energy derived from ATP hydrolysis, and then translocates them to the proteolytic subunit (CLPP) of the ClpXP complex for degradation (PubMed:11923310, PubMed:22710082, PubMed:28874591). Thanks to its chaperone activity, it also functions in the incorporation of the pyridoxal phosphate cofactor into 5-aminolevulinate synthase, thereby activating 5-aminolevulinate (ALA) synthesis, the first step in heme biosynthesis (PubMed:28874591). This chaperone is also involved in the control of mtDNA nucleoid distribution, by regulating mitochondrial transcription factor A (TFAM) activity (PubMed:22841477)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Mitochondrion. Mitochondrion matrix, mitochondrion nucleoid
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of O76031
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
309 |
KTLLAQTLAK C LDVPFAICDC |
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| 2 |
586 |
MFEVPNSDIV C VEVDKEVVEG |
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