Protein Name:
Glutaredoxin-3
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UniprotKB/SwissProt ID: O76003 (O76003)
Gene Name:
GLRX3
Organism: Homo sapiens (Human)
Function: Together with BOLA2, acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins (PubMed:26613676, PubMed:27519415). Acts as a critical negative regulator of cardiac hypertrophy and a positive inotropic regulator (By similarity). Required for hemoglobin maturation (PubMed:23615448). Does not possess any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm, cytosol. Cytoplasm, cell cortex. Cytoplasm, myofibril, sarcomere, Z line
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of O76003
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
146 |
RLKKLTHAAP C MLFMKGTPQE |
CCCCHHHHHH H HHHHHCCCCC |
2.95% |
24105792
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| 2 |
229 |
LEASEELDTI C PKAPKLEERL |
CCCCHHHHHH H HHHHHCCCCC |
2.84% |
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