Protein Name:
Triple functional domain protein
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UniprotKB/SwissProt ID: O75962 (O75962)
Gene Name:
TRIO
Organism: Homo sapiens (Human)
Function: Guanine nucleotide exchange factor (GEF) for RHOA and RAC1 GTPases (PubMed:22155786, PubMed:27418539, PubMed:8643598). Involved in coordinating actin remodeling, which is necessary for cell migration and growth (PubMed:10341202, PubMed:22155786). Plays a key role in the regulation of neurite outgrowth and lamellipodia formation (PubMed:32109419). In developing hippocampal neurons, limits dendrite formation, without affecting the establishment of axon polarity. Once dendrites are formed, involved in the control of synaptic function by regulating the endocytosis of AMPA-selective glutamate receptors (AMPARs) at CA1 excitatory synapses (By similarity). May act as a regulator of adipogenesis (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Cell projection
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of O75962
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
1041 |
EQEYKREEDW C GGADKLGPNS |
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| 2 |
640 |
AAEQLAQTGE C DPEEIYQAAH |
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