Protein Name:
Isocitrate dehydrogenase [NADP] cytoplasmic
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UniprotKB/SwissProt ID: O75874 (O75874)
Gene Name:
IDH1
Organism: Homo sapiens (Human)
Function: Catalyzes the NADP(+)-dependent oxidative decarboxylation of isocitrate (D-threo-isocitrate) to 2-ketoglutarate (2-oxoglutarate), which is required by other enzymes such as the phytanoyl-CoA dioxygenase (PubMed:10521434, PubMed:19935646). Plays a critical role in the generation of NADPH, an important cofactor in many biosynthesis pathways (PubMed:10521434). May act as a corneal epithelial crystallin and may be involved in maintaining corneal epithelial transparency (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm, cytosol. Peroxisome
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of O75874
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
114 |
GGTVFREAII C KNIPRLVSGW |
CCCCCCCCCE E EECHHHHHHH |
1.95% |
24105792
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| 2 |
269 |
MKSEGGFIWA C KNYDGDVQSD |
CCCCCCCCCE E EECHHHHHHH |
1.44% |
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| 3 |
297 |
SLGMMTSVLV C PDGKTVEAEA |
CCCCCCCCCE E EECHHHHHHH |
1.91% |
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| 4 |
379 |
AGFMTKDLAA C IKGLPNVQRS |
CCCCCCCCCE E EECHHHHHHH |
2.48% |
24105792
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| 5 |
73 |
AIKKHNVGVK C ATITPDEKRV |
CCCCCCCCCE E EECHHHHHHH |
3.62% |
24105792
37478858
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