Protein Name:
Carbonyl reductase [NADPH] 3
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UniprotKB/SwissProt ID: O75828 (O75828)
Gene Name:
CBR3
Organism: Homo sapiens (Human)
Function: Catalyzes the NADPH-dependent reduction of carbonyl compounds to their corresponding alcohols (PubMed:18493841). Has low NADPH-dependent oxidoreductase activity. Acts on several orthoquinones, acts as well on non-quinone compounds, such as isatin or on the anticancer drug oracin (PubMed:15537833, PubMed:18493841, PubMed:19841672). Best substrates for CBR3 is 1,2- naphthoquinone, hence could play a role in protection against cytotoxicity of exogenous quinones (PubMed:19841672). Exerts activity toward ortho-quinones but not paraquinones. No endogenous substrate for CBR3 except isatin has been identified (PubMed:19841672)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of O75828
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
143 |
GRVVNISSLQ C LRAFENCSED |
CCCCCCEEEC C CCCCCHHHHH |
3.17% |
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| 2 |
150 |
SLQCLRAFEN C SEDLQERFHS |
CCCCCCEEEC C CCCCCHHHHH |
3.57% |
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| 3 |
226 |
RKADRILVNA C CPGPVKTDMD |
CCCCCCEEEC C CCCCCHHHHH |
2.13% |
19483679
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| 4 |
227 |
KADRILVNAC C PGPVKTDMDG |
CCCCCCEEEC C CCCCCHHHHH |
3.97% |
19483679
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