Protein Name:
Protein phosphatase 1B
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UniprotKB/SwissProt ID: O75688 (O75688)
Gene Name:
PPM1B
Organism: Homo sapiens (Human)
Function: Enzyme with a broad specificity. Dephosphorylates CDK2 and CDK6 in vitro. Dephosphorylates PRKAA1 and PRKAA2. Inhibits TBK1-mediated antiviral signaling by dephosphorylating it at 'Ser-172'. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm, cytosol. Membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of O75688
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
163 |
RAVLYRNGQV C FSTQDHKPCN |
CCCCCCCCCC C CCCCCCCCCC |
1.39% |
22178444
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| 2 |
172 |
VCFSTQDHKP C NPREKERIQN |
CCCCCCCCCC C CCCCCCCCCC |
15.15% |
22178444
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| 3 |
272 |
LEVSDDLENV C NWVVDTCLHK |
CCCCCCCCCC C CCCCCCCCCC |
5.11% |
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