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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Mitochondrial tRNA-specific 2-thiouridylase 1

UniprotKB/SwissProt ID: O75648 (O75648)

Gene Name: TRMU

Organism: Homo sapiens (Human)

Function: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Mitochondrion

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR004506 MnmA-like
IPR046885 MnmA-like_C
IPR046884 MnmA-like_central
IPR023382 MnmA-like_central_sf
IPR014729 Rossmann-like_a/b/a_fold

The S-nitrosylation sites of O75648

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 101 KGRTPNPDIV C NKHIKFSCFF