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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Filamin-B
UniprotKB/SwissProt ID: O75369 (O75369)

Gene Name: FLNB

Organism: Homo sapiens (Human)

Function: Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, stress fiber. Cytoplasm, myofibril, sarcomere, Z line. Cytoplasm, cytoskeleton, stress fiber. Cytoplasm, cytoskeleton, stress fiber. Cytoplasm, cytoskeleton

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR001589 Actinin_actin-bd_CS
IPR001715 CH_dom
IPR036872 CH_dom_sf
IPR044801 Filamin
IPR017868 Filamin/ABP280_repeat-like
IPR001298 Filamin/ABP280_rpt
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
The S-nitrosylation sites of O75369
No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 1081 GGLGLTVEGP C EAKIECSDNG  CCCCHHHHHC C CCHHHHHHHH  13.44% 2212679
2 1158 VGEAGLLSVD C SEAGPGALGL  CCCCHHHHHC C CCHHHHHHHH  3.57%
3 1280 IANPSGASTE C FVTDNADGTY  CCCCHHHHHC C CCHHHHHHHH  3.17%
4 1326 SPFKVAVTEG C QPSRVQAQGP  CCCCHHHHHC C CCHHHHHHHH  4.35% 20140087
5 1383 INCRDNKDGS C SAEYIPFAPG  CCCCHHHHHC C CCHHHHHHHH  5.67%
6 1617 RATQTGDASK C LATGPGIAST  CCCCHHHHHC C CCHHHHHHHH  2.64% 2212679
7 1650 AKTAGKGKVT C TVLTPDGTEA  CCCCHHHHHC C CCHHHHHHHH  2.51%
8 1720 TAVEEAPVNA C PPGFRPWVTE  CCCCHHHHHC C CCHHHHHHHH  3.35%
9 1868 IEGPSKAEIS C IDNKDGTCTV  CCCCHHHHHC C CCHHHHHHHH  5.79%
10 1876 ISCIDNKDGT C TVTYLPTLPG  CCCCHHHHHC C CCHHHHHHHH  3.35%
11 1952 IKAPSGRDEP C LLKRLPNNHI  CCCCHHHHHC C CCHHHHHHHH  6.99%
12 2057 IQTEDLEDGT C KVSYFPTVPG  CCCCHHHHHC C CCHHHHHHHH  5.11%
13 2115 APSVATVGSI C DLNLKIPEIN  CCCCHHHHHC C CCHHHHHHHH  5.36%
14 2248 ITFDDHKNGS C GVSYIAQEPG  CCCCHHHHHC C CCHHHHHHHH  7.09%
15 2333 VHSPSGAVEE C HVSELEPDKY  CCCCHHHHHC C CCHHHHHHHH  2.13%
16 2431 IEGPSKVKMD C QETPEGYKVM  CCCCHHHHHC C CCHHHHHHHH  3.35%
17 2501 ESVTRSSTET C YSAIPKASSD  CCCCHHHHHC C CCHHHHHHHH  1.74%
18 2537 VGQKSSFLVD C SKAGSNMLLI  CCCCHHHHHC C CCHHHHHHHH  3.33% 2212679
19 2556 LIGVHGPTTP C EEVSMKHVGN  CCCCHHHHHC C CCHHHHHHHH  7% 2212679
20 26 KIQQNTFTRW C NEHLKCVNKR  CCCCHHHHHC C CCHHHHHHHH  3.74%
21 416 VEDKGNQVYR C VYKPMQPGPH  CCCCHHHHHC C CCHHHHHHHH  1.83%
22 450 SPFVVQVGEA C NPNACRASGR  CCCCHHHHHC C CCHHHHHHHH  8.28% 2212679
23 455 QVGEACNPNA C RASGRGLQPK  CCCCHHHHHC C CCHHHHHHHH  4.79%
24 604 IEYNDQNDGS C DVKYWPKEPG  CCCCHHHHHC C CCHHHHHHHH  9.48% 19483679
25 622 EPGEYAVHIM C DDEDIKDSPY  CCCCHHHHHC C CCHHHHHHHH  6.2%
26 660 AYGPGLEKSG C IVNNLAEFTV  CCCCHHHHHC C CCHHHHHHHH  3.97% 19483679
27 706 MKNRMDGTYA C SYTPVKAIKH  CCCCHHHHHC C CCHHHHHHHH  1.94%
28 769 ANEPTHFTVD C TEAGEGDVSV  CCCCHHHHHC C CCHHHHHHHH  3.01%
29 991 ILSPSRKVVP C LVTPVTGREN  CCCCHHHHHC C CCHHHHHHHH  3.01%