Protein Name:
Vacuolar protein sorting-associated protein 4B
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UniprotKB/SwissProt ID: O75351 (O75351)
Gene Name:
VPS4B
Organism: Homo sapiens (Human)
Function: Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their ATP-dependent disassembly, possibly in combination with membrane fission (PubMed:18687924). Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. VPS4A/B are required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413) (Microbial infection) In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Late endosome membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of O75351
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
240 |
IIFIDEIDSL C GSRSENESEA |
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| 2 |
384 |
NHLVDDLLTP C SPGDPGAIEM |
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| 3 |
62 |
DKAKQSIRAK C TEYLDRAEKL |
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