Protein Name:
Ankyrin repeat domain-containing protein 17
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UniprotKB/SwissProt ID: O75179 (O75179)
Gene Name:
ANKRD17
Organism: Homo sapiens (Human)
Function: Could play pivotal roles in cell cycle and DNA regulation (PubMed:19150984). Involved in innate immune defense against viruse by positively regulating the viral dsRNA receptors DDX58 and IFIH1 signaling pathways (PubMed:22328336). Involves in NOD2- and NOD1-mediated responses to bacteria suggesting a role in innate antibacterial immune pathways too (PubMed:23711367). Target of enterovirus 71 which is the major etiological agent of HFMD (hand, foot and mouth disease) (PubMed:17276651). Could play a central role for the formation and/or maintenance of the blood vessels of the circulation system (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Nucleus
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of O75179
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
1091 |
SNHDTALTLA C AGGHEELVQT |
CCCCCCCCCH H HHCCCCCCCC |
3.98% |
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| 2 |
1158 |
RTKDTPLSLA C SGGRQEVVEL |
CCCCCCCCCH H HHCCCCCCCC |
4.75% |
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| 3 |
1260 |
TNRNTALTLA C FQGRTEVVSL |
CCCCCCCCCH H HHCCCCCCCC |
2.69% |
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| 4 |
1336 |
IAADKGHYKF C ELLIGRGAHI |
CCCCCCCCCH H HHCCCCCCCC |
2.93% |
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| 5 |
1437 |
DKEMLKKCHL C MESIVQAKDR |
CCCCCCCCCH H HHCCCCCCCC |
0.95% |
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| 6 |
1622 |
GDSDNMRISS C SDESSNSNSS |
CCCCCCCCCH H HHCCCCCCCC |
4.79% |
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| 7 |
1690 |
SEGTSNSLST C TKSGPSPLSS |
CCCCCCCCCH H HHCCCCCCCC |
3.97% |
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| 8 |
1746 |
VISRVIGRGG C NINAIREFTG |
CCCCCCCCCH H HHCCCCCCCC |
5.28% |
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| 9 |
2063 |
GGVSRNSPLD C GSASPNKVAS |
CCCCCCCCCH H HHCCCCCCCC |
6.46% |
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| 10 |
210 |
VLRRLTSSVS C ALDEAAAALT |
CCCCCCCCCH H HHCCCCCCCC |
4.01% |
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| 11 |
242 |
QSDNRSLAEA C SEGDVNAVRK |
CCCCCCCCCH H HHCCCCCCCC |
2.61% |
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| 12 |
409 |
EFKESALTLA C YKGHLEMVRF |
CCCCCCCCCH H HHCCCCCCCC |
3.97% |
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| 13 |
476 |
SFESPLTLAA C GGHVELAALL |
CCCCCCCCCH H HHCCCCCCCC |
5.81% |
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| 14 |
542 |
ETQETALTLA C CGGFLEVADF |
CCCCCCCCCH H HHCCCCCCCC |
2.2% |
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| 15 |
543 |
TQETALTLAC C GGFLEVADFL |
CCCCCCCCCH H HHCCCCCCCC |
5.06% |
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| 16 |
564 |
IKAGADIELG C STPLMEAAQE |
CCCCCCCCCH H HHCCCCCCCC |
6.82% |
24105792
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| 17 |
58 |
ASSPRGMVRV C DLLLKKKPPQ |
CCCCCCCCCH H HHCCCCCCCC |
1.82% |
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| 18 |
605 |
ATGDTALTYA C ENGHTDVADV |
CCCCCCCCCH H HHCCCCCCCC |
2.69% |
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| 19 |
644 |
LMKAARAGHV C TVQFLISKGA |
CCCCCCCCCH H HHCCCCCCCC |
2.27% |
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| 20 |
672 |
NNDHTVLSLA C AGGHLAVVEL |
CCCCCCCCCH H HHCCCCCCCC |
4.36% |
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| 21 |
714 |
AAKGGHTSVV C YLLDYPNNLL |
CCCCCCCCCH H HHCCCCCCCC |
1.53% |
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| 22 |
906 |
IQLQQQQQQS C QHLGLLTPVG |
CCCCCCCCCH H HHCCCCCCCC |
2.28% |
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