Protein Name:
Protein cordon-bleu
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UniprotKB/SwissProt ID: O75128 (O75128)
Gene Name:
COBL
Organism: Homo sapiens (Human)
Function: Plays an important role in the reorganization of the actin cytoskeleton. Regulates neuron morphogenesis and increases branching of axons and dendrites. Regulates dendrite branching in Purkinje cells (By similarity). Binds to and sequesters actin monomers (G actin). Nucleates actin polymerization by assembling three actin monomers in cross-filament orientation and thereby promotes growth of actin filaments at the barbed end. Can also mediate actin depolymerization at barbed ends and severing of actin filaments. Promotes formation of cell ruffles
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Cytoplasm, cytoskeleton. Cell projection, ruffle. Cytoplasm
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of O75128
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
654 |
NAKVKDKVYG C ADGERTQATE |
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| 2 |
975 |
DRPAAIHRSS C FSLVQSSQRD |
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| 3 |
993 |
QRDRVSVGQS C GFSGKQSTSS |
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